Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease
Identifieur interne : 000799 ( Main/Corpus ); précédent : 000798; suivant : 000800Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease
Auteurs : Angelo Antonini ; Chiara Siri ; Gabriella Santangelo ; Roberto Cilia ; Michele Poletti ; Margherita Canesi ; Alessandra Caporali ; Francesca Mancini ; Gianni Pezzoli ; Roberto Ceravolo ; Ubaldo Bonuccelli ; Paolo BaroneSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
English descriptors
Abstract
Background:: Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort. Methods:: 103 consecutive newly diagnosed drug‐naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS‐11) and Maudsley Obsessional‐Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive‐compulsive symptoms, respectively. Depression (GDS‐15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls. Results:: 17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM‐IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS‐11 attentive‐impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; P = 0.007) and in MOCQ/R‐Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; P = 0.007) in PD with ICD. We also observed a positive correlation between GDS‐15 and BIS‐11. Conclusions:: Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23501
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department for Parkinson's Disease, IRCCS San Camillo, Venice and University of Padua, Venice, Italy</mods:affiliation></affiliation></author><author><name sortKey="Siri, Chiara" sort="Siri, Chiara" uniqKey="Siri C" first="Chiara" last="Siri">Chiara Siri</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Diagnosis and Care, Hermitage‐Capodimonte, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Poletti, Michele" sort="Poletti, Michele" uniqKey="Poletti M" first="Michele" last="Poletti">Michele 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Italy</mods:affiliation></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation><mods:affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FEBA60850AD60B8B66A4B497347A767D211171EF</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23501</idno><idno type="url">https://api.istex.fr/document/FEBA60850AD60B8B66A4B497347A767D211171EF/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000799</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department for Parkinson's Disease, IRCCS San Camillo, Venice and University of Padua, Venice, Italy</mods:affiliation></affiliation></author><author><name sortKey="Siri, Chiara" sort="Siri, Chiara" uniqKey="Siri C" first="Chiara" last="Siri">Chiara Siri</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Diagnosis and Care, Hermitage‐Capodimonte, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Poletti, Michele" sort="Poletti, Michele" uniqKey="Poletti M" first="Michele" last="Poletti">Michele Poletti</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Canesi, Margherita" sort="Canesi, Margherita" uniqKey="Canesi M" first="Margherita" last="Canesi">Margherita Canesi</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Caporali, Alessandra" sort="Caporali, Alessandra" uniqKey="Caporali A" first="Alessandra" last="Caporali">Alessandra Caporali</name><affiliation><mods:affiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mancini, Francesca" sort="Mancini, Francesca" uniqKey="Mancini F" first="Francesca" last="Mancini">Francesca Mancini</name><affiliation><mods:affiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation><mods:affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="464">464</biblScope><biblScope unit="page" to="468">468</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FEBA60850AD60B8B66A4B497347A767D211171EF</idno><idno type="DOI">10.1002/mds.23501</idno><idno type="ArticleID">MDS23501</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>compulsivity</term><term>drug naïve</term><term>impulse control disorders</term><term>impulsivity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort. Methods:: 103 consecutive newly diagnosed drug‐naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS‐11) and Maudsley Obsessional‐Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive‐compulsive symptoms, respectively. Depression (GDS‐15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls. Results:: 17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM‐IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS‐11 attentive‐impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; P = 0.007) and in MOCQ/R‐Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; P = 0.007) in PD with ICD. We also observed a positive correlation between GDS‐15 and BIS‐11. Conclusions:: Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Angelo Antonini MD</name><affiliations><json:string>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string><json:string>Department for Parkinson's Disease, IRCCS San Camillo, Venice and University of Padua, Venice, Italy</json:string></affiliations></json:item><json:item><name>Chiara Siri PsyD</name><affiliations><json:string>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Gabriella Santangelo PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</json:string><json:string>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</json:string><json:string>Department of Diagnosis and Care, Hermitage‐Capodimonte, Naples, Italy</json:string></affiliations></json:item><json:item><name>Roberto Cilia MD</name><affiliations><json:string>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Michele Poletti PsyD</name><affiliations><json:string>Neurology Unit, USL of Viareggio, Viareggio, Italy</json:string></affiliations></json:item><json:item><name>Margherita Canesi MD</name><affiliations><json:string>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Alessandra Caporali PsyD</name><affiliations><json:string>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</json:string></affiliations></json:item><json:item><name>Francesca Mancini MD</name><affiliations><json:string>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</json:string></affiliations></json:item><json:item><name>Gianni Pezzoli MD</name><affiliations><json:string>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Roberto Ceravolo MD</name><affiliations><json:string>Department of Neurosciences, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Ubaldo Bonuccelli MD</name><affiliations><json:string>Neurology Unit, USL of Viareggio, Viareggio, Italy</json:string><json:string>Department of Neurosciences, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drug naïve</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>impulse control disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>impulsivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>compulsivity</value></json:item></subject><articleId><json:string>MDS23501</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort. Methods:: 103 consecutive newly diagnosed drug‐naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS‐11) and Maudsley Obsessional‐Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive‐compulsive symptoms, respectively. Depression (GDS‐15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls. Results:: 17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM‐IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS‐11 attentive‐impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; P = 0.007) and in MOCQ/R‐Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; P = 0.007) in PD with ICD. We also observed a positive correlation between GDS‐15 and BIS‐11. Conclusions:: Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.395</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1863</abstractCharCount><pdfWordCount>3395</pdfWordCount><pdfCharCount>22278</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>260</abstractWordCount></qualityIndicators><title>Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>468</last><first>464</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23501</json:string></doi><id>FEBA60850AD60B8B66A4B497347A767D211171EF</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/FEBA60850AD60B8B66A4B497347A767D211171EF/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/FEBA60850AD60B8B66A4B497347A767D211171EF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FEBA60850AD60B8B66A4B497347A767D211171EF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title><author><persName><forename type="first">Angelo</forename><surname>Antonini</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><affiliation>Department for Parkinson's Disease, IRCCS San Camillo, Venice and University of Padua, Venice, Italy</affiliation></author><author><persName><forename type="first">Chiara</forename><surname>Siri</surname></persName><roleName type="degree">PsyD</roleName><note type="correspondence"><p>Correspondence: Parkinson Institute, Istituti Clinici di Perfezionamento, Milano 20126, Italy</p></note><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Gabriella</forename><surname>Santangelo</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</affiliation><affiliation>Department of Diagnosis and Care, Hermitage‐Capodimonte, Naples, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Cilia</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Michele</forename><surname>Poletti</surname></persName><roleName type="degree">PsyD</roleName><affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</affiliation></author><author><persName><forename type="first">Margherita</forename><surname>Canesi</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Alessandra</forename><surname>Caporali</surname></persName><roleName type="degree">PsyD</roleName><affiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</affiliation></author><author><persName><forename type="first">Francesca</forename><surname>Mancini</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</affiliation></author><author><persName><forename type="first">Gianni</forename><surname>Pezzoli</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Ceravolo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Ubaldo</forename><surname>Bonuccelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</affiliation><affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="464">464</biblScope><biblScope unit="page" to="468">468</biblScope></imprint></monogr><idno type="istex">FEBA60850AD60B8B66A4B497347A767D211171EF</idno><idno type="DOI">10.1002/mds.23501</idno><idno type="ArticleID">MDS23501</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort. Methods:: 103 consecutive newly diagnosed drug‐naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS‐11) and Maudsley Obsessional‐Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive‐compulsive symptoms, respectively. Depression (GDS‐15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls. Results:: 17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM‐IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS‐11 attentive‐impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; P = 0.007) and in MOCQ/R‐Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; P = 0.007) in PD with ICD. We also observed a positive correlation between GDS‐15 and BIS‐11. Conclusions:: Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>drug naïve</term></item><item><term>impulse control disorders</term></item><item><term>impulsivity</term></item><item><term>compulsivity</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-03-29">Received</change><change when="2010-09-30">Registration</change><change when="2011-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FEBA60850AD60B8B66A4B497347A767D211171EF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v26.3</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2011-02-15">15 February 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="180" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23501</doi><idGroup><id type="unit" value="MDS23501"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-03-29"></event><event type="manuscriptRevised" date="2010-08-02"></event><event type="manuscriptAccepted" date="2010-09-30"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-12"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-02-10"></event><event type="publishedOnlineFinalForm" date="2011-03-31"></event><event type="firstOnline" date="2011-02-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">464</numbering><numbering type="pageLast">468</numbering></numberingGroup><correspondenceTo>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano 20126, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23501.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="29"></count><count type="wordTotal" number="4589"></count></countGroup><titleGroup><title type="main" xml:lang="en">Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease<link href="#fn2"></link></title><title type="short" xml:lang="en">Impulsivity and Compulsivity in Drug‐Naïve PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Angelo</givenNames><familyName>Antonini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Chiara</givenNames><familyName>Siri</familyName><degrees>PsyD</degrees></personName><contactDetails><email>chiara.siri@parkinson.it</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3 #af4 #af5"><personName><givenNames>Gabriella</givenNames><familyName>Santangelo</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Roberto</givenNames><familyName>Cilia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Michele</givenNames><familyName>Poletti</familyName><degrees>PsyD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Margherita</givenNames><familyName>Canesi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Alessandra</givenNames><familyName>Caporali</familyName><degrees>PsyD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Francesca</givenNames><familyName>Mancini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Gianni</givenNames><familyName>Pezzoli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Roberto</givenNames><familyName>Ceravolo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af6 #af8"><personName><givenNames>Ubaldo</givenNames><familyName>Bonuccelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Department for Parkinson's Disease, IRCCS San Camillo, Venice and University of Padua, Venice, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Department of Diagnosis and Care, Hermitage‐Capodimonte, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="IT" type="organization"><unparsedAffiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="IT" type="organization"><unparsedAffiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">drug naïve</keyword><keyword xml:id="kwd3">impulse control disorders</keyword><keyword xml:id="kwd4">impulsivity</keyword><keyword xml:id="kwd5">compulsivity</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>103 consecutive newly diagnosed drug‐naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS‐11) and Maudsley Obsessional‐Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive‐compulsive symptoms, respectively. Depression (GDS‐15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM‐IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS‐11 attentive‐impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; <i>P</i> = 0.007) and in MOCQ/R‐Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; <i>P</i> = 0.007) in PD with ICD. We also observed a positive correlation between GDS‐15 and BIS‐11.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Impulsivity and Compulsivity in Drug‐Naïve PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Impulsivity and compulsivity in drug‐naïve patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Angelo</namePart><namePart type="family">Antonini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><affiliation>Department for Parkinson's Disease, IRCCS San Camillo, Venice and University of Padua, Venice, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chiara</namePart><namePart type="family">Siri</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><description>Correspondence: Parkinson Institute, Istituti Clinici di Perfezionamento, Milano 20126, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gabriella</namePart><namePart type="family">Santangelo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</affiliation><affiliation>Department of Diagnosis and Care, Hermitage‐Capodimonte, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Cilia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michele</namePart><namePart type="family">Poletti</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margherita</namePart><namePart type="family">Canesi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandra</namePart><namePart type="family">Caporali</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Mancini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, Casa di Cura San Pio X, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gianni</namePart><namePart type="family">Pezzoli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Ceravolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ubaldo</namePart><namePart type="family">Bonuccelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, USL of Viareggio, Viareggio, Italy</affiliation><affiliation>Department of Neurosciences, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-02-15</dateIssued><dateCaptured encoding="w3cdtf">2010-03-29</dateCaptured><dateValid encoding="w3cdtf">2010-09-30</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">29</extent><extent unit="words">4589</extent></physicalDescription><abstract lang="en">Background:: Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort. Methods:: 103 consecutive newly diagnosed drug‐naïve PD patients (means: age = 60.5 ± 9.2 years; duration = 15.4 ± 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS‐11) and Maudsley Obsessional‐Compulsive Questionnaire (MOCQ/R) assessed impulsivity, obsessive‐compulsive symptoms, respectively. Depression (GDS‐15) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls. Results:: 17.5% of PD patients screened positive for at least one ICD at MIDI (17/103) and SOGS (1/103), though none had a disorder based on DSM‐IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS‐11 attentive‐impulsivity subscale (15.2 ± 4.8 vs. 18.7 ± 4.9; P = 0.007) and in MOCQ/R‐Doubting subscale (0.67 ± 1.1 vs. 1.5 ± 1.2; P = 0.007) in PD with ICD. We also observed a positive correlation between GDS‐15 and BIS‐11. Conclusions:: Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>drug naïve</topic><topic>impulse control disorders</topic><topic>impulsivity</topic><topic>compulsivity</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>464</start><end>468</end><total>5</total></extent></part></relatedItem><identifier type="istex">FEBA60850AD60B8B66A4B497347A767D211171EF</identifier><identifier type="DOI">10.1002/mds.23501</identifier><identifier type="ArticleID">MDS23501</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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